Indirect Electrothermal Atomization Atomic Absorption Spectrometric Determination of the Drug Desferrioxamine in Some Pharmaceutical Preparations Using Vanadium (V) as a Mediating Element

[摘要]   A method has been developed for the determination of the drug Desferrioxamine (DFOM) in some pharmaceuticals using indirect electrothermal atomic absorption spectrometry (ETAAS) supplied with zirconium-coated graphite tube and V (V) as a mediating metal. Vanadium (V) forms a chelate complex with (DFOM) at  pH  range 1-1.5  which could be extracted with benzyl alcohol under certain experimental conditions  .Aliquots of the extracts are  injected  into the coated graphite furnace and the atomic absorption signals are measured .  A standard calibration graph was constructed and from which several parameters and figures of merit were found, such as: linear range (0.5-19 μg  mL ^–1) of DFOM, relative standard deviation (1.44-1.68%); low of detection (0.12 μg mL ^–1)sensitivity. (424.2 pg), recovery %( 101.57± 0.147) and relative error (1.57%).  The mole ratio method has been used to determine the structure of chelate DFOM: V (V) and found to be 1:1. The developed procedure is applied to analyze DFOM in several commercially available pharmaceuticals using direct and standard additions methods and results are comparable. All statistical calculations are implemented via a Minitab software version 11.

[学科分类] 分析化学

[关键词] Ivabradine HCL;Pharmaceutical Dosage Form;RP-HPLC. Spectrophotometric;UV detector