Micellar Studies of Local Anticonvulsant Gabapentin in Aqueous Electrolyte Solution

[摘要] Specific conductivity of aqueous electrolyte solution of anticonvulsant gabapentin (2-[1-(aminomethyl)cyclohexyl]ethanoicacid) has been determined in the temperature range of 303-338 K. The critical micelle concentrations (cmc), ionization degree (a) and the counterion binding of the micelle (b), were estimated from the dependence of specific conductivity on concentration. Thermodynamic parameters, such as standard Gibbs free energy (DG^o), enthalpy (DH^o) and entropy (DS^o) of micellization, were estimated by the mass action model.

[学科分类] 分析化学

[关键词] Spectrophotometry; Artesunate; Falcigo; Safranin O; Variamine blue