Comparison of FT-NIR and HPLC for Green Approach to Assay Cefixime in Its Pharmaceutical Capsules

[摘要] Near-infrared spectroscopy (NIRS) has become an analytical technique of great interest for the pharmaceutical industry, particularly as a greener analytical technique. In this paper a calibration model for cefixime in the capsules pharmaceutical dosage form was built by utilizing chemometric processing based mainly on a partial least square regression fit to assay the material using NIR technique. The results obtained by NIR spectroscopy were compared with the compendial HPLC method for cefixime capsules produced by USP. The present study showed that cefixime capsules can be individually analyzed by NIR with high accuracy. This proposed technique realizes a lot of green analytical aspects in developing eco-friendly analytical method

[学科分类] 分析化学

[关键词] : cefixime capsules;FT-NIR transmission;GAC (green analytical chemistry);HPLC assay;PAT (process analytical technology);validation; PLS model