Frequencies of Interleukin 1 Gene Polymorphisms in Koreans

[摘要] The interleukin-1 (IL-1) family consists of three different cytokines: two pro-inflammatory cytokines, IL-1α and IL-1β, and an IL-1 inhibitor, IL-1 receptor antagonist (IL-1ra). The genes for IL-1α, IL-1β, and IL-1ra, located in a cluster on human chromosome 2, have several polymorphisms. IL-1α has a base-exchange polymorphism at position −889 in the promoter region (1). IL-1β has two base-exchange polymorphisms: at position −511 in the promoter region and at position +3953 in exon 5 (2). The IL-1ra gene has a pentaallelic polymorphic site in intron 2, containing variable numbers of an 86-bp identical tandem repeat (VNTR) (3). These polymorphisms of IL-1β and IL-1ra have an effect on cytokine production in vitro. In addition, …

[学科分类] 过敏症与临床免疫学