Serum Concentrations of Vascular Endothelial Growth Factor in Advanced Non-Small Cell Lung Cancer

[摘要] Vascular endothelial growth factor (VEGF) may play a role in tumor growth. Several biological activities of VEGF favor the growth of solid tumors, including mitogenic activity for vascular endothelial cells and inhibition of immature dendritic cells with a consequent decrease in immunity. VEGF is regulated by hypoxia, growth factors, interleukin-1 and -6, the oncogene ras , and the tumor suppressor gene p53 (1).The role of VEGF in non-small cell lung cancer (NSCLC) patients treated with chemotherapy in still undetermined. We studied the serum concentrations of this cytokine in NSCLC patients with advanced disease and its correlation with carcinoembryonic antigen (CEA), CYFRA 21-1, CA125, and C-reactive protein (CRP).We analyzed 33 healthy individuals, 23 patients with benign pulmonary disease (13 …

[学科分类] 过敏症与临床免疫学