Formaldehyde-Forming Drugs and Urinary 17-Hydroxycorticosteroids

[摘要] An apparent elevation of urinary 17-hydroxycorticosteroids may be found in the urine of patients receiving the formaldehyde-forming drug Mandelamine (methenamine mandelate), when the assay procedure depends on the formation of colored compounds with phenylhydrazine as determined at 1 wavelength (410 mµ). This false elevation may be eliminated by reading absorption at 3 wavelengths and using the Allen correction. However, the determination of 17-ketogenic steroids is not influenced by the presence of formaldehyde in the urine. Administration of Mandelamine or other formaldehyde-forming drugs should be stopped prior to the collection of urine in order to eliminate a potential source of error in determining 17-hydroxycorticosteroid excretion.

[学科分类] 过敏症与临床免疫学