Comparison Between Thiocholinesters and o-Nitrophenylbutyrate as Substrates in the Assay of Serum Cholinesterase

[摘要] The technical and clinical usefulness of three substrates for serum cholinesterase were compared. The diagnostic value of acetylthiocholine was equal to that of butyrylthiocholine and superior to that of o-nitrophenylbutyrate. Technically, butyrylthiocholine is superior to the other two substrates chiefly because of its greater affinity for serum cholinesterase. A kinetic method using o-nitrophenylbutyrate is described that is capable of carrying out 60 tests per hour with good results.

[学科分类] 过敏症与临床免疫学