Apolipoprotein A-IV in the Fed and Fasting States

[摘要] Apolipoprotein A-IV (apo A-IV) is a 46-kDa plasma protein (1) with different isoforms (2). It is secreted with chylomicrons into the circulation (3). Within the plasma compartment, apo A-IV dissociates from chylomicrons (4) and associates with HDL, triglyceride-rich lipoproteins, and the lipoprotein-free fraction (5).Apo A-IV is influenced by dietary intervention, and a low-fat, low-cholesterol diet (NCEP Step II diet) and is able to decrease apo A-IV secretion rates significantly (6). Apo A-IV is catabolized rapidly with a fractional catabolic rate of ∼2.4 pools/day (7). Apo A-IV is higher in patients with renal …

[学科分类] 过敏症与临床免疫学