Framingham Study Insights on Diabetes and Cardiovascular Disease

[摘要] Featured Article: Kannel WB, McGee DL. Diabetes and cardiovascular disease: the Framingham study. JAMA 1979;241:2035–8.3This diabetes report extended prior Framingham study findings with more-robust 20-year data for estimating the relative risk of specified atherosclerotic cardiovascular events from prior diabetes. It prospectively compared the cardiovascular impact of diabetes in women vs men, revealing the greater vulnerability in women. The role of diabetes as a contributor to atherosclerotic cardiovascular disease (CVD) was uncertain at the time of the report, with some doubting whether diabetes actually caused coronary disease. This and prior Framingham study reports confirmed prospectively in a general population sample the clinical observations of medical practitioners—that their patients with diabetes had excessive occurrence of peripheral artery disease, coronary disease, and strokes. The report also highlighted the less appreciated fact of a high risk of heart failure in patients with diabetes. The most notable unique feature of the report was that it revealed that the impact of diabetes varied both in relation to specific cardiovascular outcomes and with the sex of the individual. The relative …

[学科分类] 过敏症与临床免疫学