Plasma Renin Activity Enzyme-Kinetic Assay: Protection of Angiotensin I from Bacterial Degradation

[摘要] To the Editor:Bystrom et al. (1) recently reported substantial peptidase activity in human plasma that had been incubated at 37 °C to generate angiotensin I (Ang I)1 during the clinical plasma renin activity (PRA) assay. If this result is correct, it would call into question many of the PRA results previously reported by our laboratory and by Quest Diagnostics, especially those with low PRA (<0.65 μg · L− · h−). We believe, however, this observation is most likely an artifact caused by a failure to follow published protocols (2, 3).Several features of the Ang I degradation reported by …

[学科分类] 过敏症与临床免疫学