In Reply

[摘要] We thank Benyamin et al. for their response to our recent article (1). We are puzzled by their statement that our Discussion implies that the association of total mortality with increased transferrin saturation is driven by the C282Y/C282Y genotype. We intentionally did not write about genetic hemochromatosis in our paper; rather, our referral to “hemochromatosis” was meant to imply hemochromatosis by any cause, genetic or otherwise. The information regarding hemochromatosis genotypes, however, is available for the participants in both the Copenhagen City Heart Study and the Copenhagen General Population Study (2, 3). We have now calculated total mortality risks for both studies combined, as a function of hemochromatosis genotype vs wild type/wild type [design and statistics as described (1)]. These risks are: 1.2 (95% CI, 1.0–1.3) for C282Y/wild type; 0.8 (95% CI, 0.6–1.1) for C282Y/H63D; and 1.3 (95% CI, …

[学科分类] 过敏症与临床免疫学