Necessity of Fractionated Urine Collection for Monitoring Patients with Cystinuria

[摘要] To the Editor:Cystinuria is an inherited form of nephrolithiasis caused by mutations in the SLC7A9 1 [solute carrier family 7 (cationic amino acid transporter, y+ system), member 9] and SLC3A1 [solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1] genes, which encode the luminal transporter b(0,+) AT subunit and rBAT subunit, respectively. The disease is characterized by impaired proximal tubular and intestinal reabsorption of cystine and the dibasic amino acids ornithine, lysine, and arginine (1). Treatment of cystinuria aims to prevent new stone formation and consists of increased fluid intake, urine alkalinization, and cystine-binding drugs for avoiding urinary cystine hypersaturation, which occurs …

[学科分类] 过敏症与临床免疫学