Commentary

[摘要] The metabolic fate of a drug can be influenced by several factors, including genetic polymorphisms in the enzymes involved in the metabolic pathways, the presence of other drugs that inhibit or induce metabolism, and the concentration of the drug. The last consideration is particularly important in overdoses, because some of the metabolic pathways that detoxify the drug may become saturated or conjugating cofactors may become depleted, leading to the accumulation of toxic metabolites that …

[学科分类] 过敏症与临床免疫学