Non-Urate Chromogens in Body Fluids

[摘要] Compounds which interfere in the analytic determination of uric acid are referred to as "non-urate chromogens." Ascorbic acid, when added to serum, causes a significant increase in apparent uric acid levels as determined by a carbonate-phosphotungstate method. The ratio of apparent urate to ascorbic acid is 1:3, a value in close agreement with that obtained for the ratio of labile non-urate chromogens to ascorbic acid in fresh plasma. Ascorbic acid, as well as most of the non-urate chromogens, can be eliminated by mild alkaline treatment prior to adding phosphotungstic acid. These results indicate that the major non-urate chromogen in the average serum is ascorbic acid. The nature of other non-urate chromogens in body fluids is reviewed.

[学科分类] 过敏症与临床免疫学