Commentary

[摘要] Tumor-induced osteomalacia (TIO)2 is a rare condition, well described in the literature. It is typically caused by tumors of mesenchymal origin that overexpress the phosphatonin fibroblast growth factor 23 (FGF-23). Patients present with bone pain, muscle weakness, and recurrent fractures. TIO has an insidious onset, and patients may have significant bone demineralization when they seek care. Hypophosphatemia is the hallmark of the disease. Laboratory data also show normal serum calcium and PTH, low or normal 25-hydroxyvitamin D, and low 1,25-dihydroxyvitamin D concentrations. Serum …

[学科分类] 过敏症与临床免疫学