Herpesviruses Encode Their Own MicroRNAs

[摘要] Featured Article: Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, Grässer FA, van Dyk LF, Ho CK, Shuman S, Chien M, Russo JJ, Ju J, Randall G, Lindenbach BD, Rice CM, Simon V, Ho DD, Zavolan M, Tuschl T. Identification of microRNAs of the herpesvirus family. Nat Methods 2005;2:269–76.2In 2001, the term microRNA (miRNA)3 was proposed for the first time after 3 groups reported the identification of hundreds of such small (22 nucleotides) noncoding RNAs in the nematode worm, Drosophila, and humans. Today, with the advent of next generation sequencing technologies, the number of validated miRNAs is nearing 2000 for humans alone, and the number of publications containing the keyword “miRNA” is up to 6000 for the year 2013. What are miRNAs? We now know quite a lot about their biogenesis, their modes of action, and their roles in a wide variety of biological processes (1). They derive from large primary transcripts, which are …

[学科分类] 过敏症与临床免疫学