New Highly Sensitivity Assay Used to Measure Cardiac Troponin T Concentration Changes During a Continuous 216-km Marathon

[摘要] We recently measured cardiac troponin T (cTnT)1 concentrations serially in blood from 10 participants of the Badwater ultramarathon, a continuous 216-km race that takes place under extreme environmental conditions. Details on the Badwater ultramarathon itself, and on the training experience and health condition of the athletes have been reported previously (1). Briefly, the athletes had completed a mean of 43.4 (median 20, range 5–130) marathons and 20.4 (median 15, range 6–80) ultramarathons, and the mean finishing times for the Badwater race were 51.24 h (median 45.2 h, range 43.5–61.4 h). cTnT was measured with a new highly sensitive assay for cardiac troponin T (Hs-TnT) (Roche Diagnostics) on an ELECSYS 2010 automated analyzer that uses chemiluminescence technology. As described previously (2), the interassay CV of this assay is 8% at 10 ng/L and 2.5% at 100 ng/L, and the intraassay CV is 5% at 10 ng/L and 1% at 100 ng/L. The diagnostic range of this assay is 2 to 10000 ng/L.Blood samples (EDTA plasma) were drawn at baseline, after …

[学科分类] 过敏症与临床免疫学