Newborn Screening for Sickle Cell Disease through Use of Tandem Mass Spectrometry

[摘要] We read with interest the recent report by Boemer et al. (1) describing the use of tandem mass spectrometry for screening of newborns for sickle cell disease. We congratulate the authors on an excellent study that follows the peptide-based philosophy and approach described in our previous publications(2)(3). Unfortunately, we believe that the authors have substantially misrepresented our data and their own originality.The authors suggest that our original communication (2) indicated that there was insufficient analytical sensitivity to distinguish homozygous and heterozygous samples. Clearly, this assertion is not the case, because we presented figures demonstrating heterozygous and homozygous signals for hemoglobin S (Hb S), …

[学科分类] 过敏症与临床免疫学