Fluorometric Assay for N-Acetylprocainamide

[摘要] We describe a simple, rapid fluorometric assay for separate quantitative analysis of procainamide and N -acetylprocainamide in mixtures. The effective linear range (fluorescence vs. concentration) in serum is 0.1 to 10.0 mg/liter, regardless of the ratio (by weight) of the two drugs from 1:10 to 10:1. Analytical recoveries by the extraction method used were 100.0 ± 3.0% and 98.0 ± 4.0%, respectively. For determination of either compound, the maximum coefficient of variation was 10%.

[学科分类] 过敏症与临床免疫学