Gas-Chromatographic and Mass-Spectrometric Detection of Low-Molecular-Weight Aliphatic Alcohols in Urine of Normal Individuals and Patients with Diabetes Mellitus

[摘要] We studied the aliphatic alcohols in 100 urines from 25 patients with diabetes mellitus under treatment with insulin, oral antidiabetic medication, or special diet. The procedure involves adsorption of the low-molecular-weight urinary metabolites on a porous polymer of 2,6-diphenyl- p -phenylene oxide (Tenax GC), gas-chromatographic separation, mass spectrometric identification, and mass fragmentographic representation of the primary alcohols by a computer. The concentrations of ethanol, n -propanol, isobutanol, n -butanol, and isopentanol are increased as compared with urine from normal persons.

[学科分类] 过敏症与临床免疫学