Commentary

[摘要] Not all neonatal jaundice is created equal. Unconjugated hyperbilirubinemia and its associated risk of kernicterus get lots of publicity but conjugated hyperbilirubinemia presents a formidable diagnostic challenge. In addition to BA, the differential diagnosis includes infection, Alagille syndrome, hypothyroidism, galactosemia, bile acid metabolic defects, cystic fibrosis, α1-antitrypsin deficiency, and genetic syndromes like PFIC (progressive familial intrahepatic cholestasis). In the case of BA, early recognition and treatment is essential to spare liver function.The first clues to cholestasis are often …

[学科分类] 过敏症与临床免疫学