Commentary

[摘要] The differential diagnosis for a necrotizing myopathy includes inherited muscle disease and acquired diseases such as toxic myopathies, hypothyroid myopathy, paraneoplastic myopathy, and the autoimmune myopathies. The most common autoimmune myopathies presenting with a necrotizing muscle biopsy are those associated with anti–signal recognition particle (anti-SRP)2 or anti–3-hydroxy-3-methylglutaryl-CoA reductase (anti-HMGCR) autoantibodies, the latter frequently occurring in the context of statin exposure. In this case, the patient's age, previously normal serum creatine kinase (CK) activities, and rapidly progressive weakness argued against an inherited myopathy. After hypothyroidism and malignancy were excluded, statin …

[学科分类] 过敏症与临床免疫学