Effects of Carboxyhemoglobin on Hemoglobinometers

[摘要] During a recent comparison of two portable hemoglobinometers designed for near-patient testing, we noted disparate readings on a quality-control material derived from human hemoglobin (Level 1, Multi-4® CO-Oximeter Controls; Instrumentation Laboratory). The insert sheet listed an acceptable range of total hemoglobin readings of 159–185 g/L (15.9–18.5 g/dL) for the OSM3 co-oximeter (Radiometer A/S). Our results on the OSM3 were at the midpoint of this range, as were results with one of the hemoglobinometers, the Hb-Quick® hemoglobinometer from Avox Systems [mean (SD), 175 (0.5) g/L; n = 5]. By contrast, readings on a HemoCue hemoglobinometer (HemoCue AB) were 16 g/L higher than the mid-range value and averaged 188 ± 1.5 g/L. Both hemoglobinometers had recently been calibrated by factory-trained employees of the respective companies.Because Level 1 controls contained ∼60% carboxyhemoglobin, we made additional measurements on fresh whole blood from a nonsmoking donor and on …

[学科分类] 过敏症与临床免疫学