Long-Term Stability of Nelfinavir Mesylate in Human Plasma

[摘要] Nelfinavir mesylate (NFV) is an HIV protease inhibitor approved for the treatment of HIV infection. Since its introduction, NFV has become a common component of standard highly active antiretroviral regimens. Although the drug has been available since 1997, the pharmacokinetic and pharmacodynamic properties of NFV and its active hydroxy- t -butylamide (M8) metabolite have not been well characterized. We recently completed investigations into the stability of NFV and M8 in plasma stored at −20 and −70 °C for up to 19 months. We observed significant degradation of both compounds in heparinized plasma samples stored at −20 °C. These results may have implications for those involved with the collection and analysis of NFV and M8 pharmacokinetic data.To facilitate our investigations, we prepared NFV and M8 calibrators in drug-free heparinized …

[学科分类] 过敏症与临床免疫学