Unsaturated Iron-binding Capacity: A Screening Test for C282Y Hemochromatosis?

[摘要] Transferrin saturation (TS) has been recommended for screening for hemochromatosis (1). It is widely available, and results may be increased even in young adults with hemochromatosis. The TS assay is a two-step assay with serum iron in the numerator and total iron-binding capacity, unsaturated iron-binding capacity (UIBC), or serum transferrin in the denominator. Serum iron/(serum iron + UIBC) equals the TS. In a previous study, we compared UIBC to TS as a screening test for C282Y hemochromatosis in a population of asymptomatic voluntary blood donors (2). Because blood donation could potentially affect iron status, we have reevaluated TS and UIBC in referred hemochromatosis patients and used first-time blood donors as control cases (n = 386, all …

[学科分类] 过敏症与临床免疫学