A High Factor II/Factor X Functional Ratio Is Not a Useful Predictor of the FII G20210A Gene Mutation in Thromboembolic Patients Undergoing Oral Anticoagulant Treatment

[摘要] A G→A transition at nucleotide 20210 in the prothrombin gene has recently been associated with venous thromboembolism in a Dutch population (1). The prevalence of this genetic variation in Western countries is 5–15% among thrombotic patients and 1–5% in healthy controls (2)(3)(4)(5). The main pathogenic mechanism appears to be the increase of plasma prothrombin (FII) because many carriers of the FII20210A mutation have hyperprothrombinemia by functional assays. However, increased FII is not specific for this mutation (1)(3)(6). Even some carriers do not exhibit hyperprothrombinemia because of the variability in vitamin K metabolism or hepatic function. A functional, rapid, low-cost assay, preferably not influenced by the oral anticoagulant (OA) (7) required by many patients, would be desirable for screening purposes. Because factor X (FX) has a half-life …

[学科分类] 过敏症与临床免疫学