Comparison of Diagnostic Performance of Three New Fast D-Dimer Assays in the Exclusion of Deep Vein Thrombosis

[摘要] D-Dimer (DD), a soluble cross-linked fibrin degradation product, has been suggested as a reliable marker to rule out deep vein thrombosis (DVT) (1)(2)(3)(4). The disease can be ruled out in approximately one-third of outpatients suspected with DVT when the plasma concentration of DD is below an appropriate cutoff value (4). Measurement of plasma DD concentrations has been performed by two major methods: ELISA, which is highly sensitive but time-consuming; and latex agglutination, which is faster but less sensitive than ELISA (2)(4). SimpliRED, a latex assay, detects DD directly in whole blood, avoiding the plasma preparation step (5). However, this assay gives only qualitative results and adds an interindividual observation bias that may partly explain the discordant sensitivity values obtained by different investigators (3)(5)(6)(7). In the present study, we investigated the clinical utility of three new fast DD assays in the diagnosis of DVT.We compared 177 consecutive outpatients (117 women and 60 men) from the Montreal cohort in a bicentric prospective study (8). The mean age was 56 years (range, 19–87 years). The inclusion criteria were that subjects be ambulatory patients with a clinical suspicion of DVT and >16 years of age. The exclusion …

[学科分类] 过敏症与临床免疫学