Association between Serum Concentrations of Persistent Organic Pollutants and γ Glutamyltransferase: Results from the National Health and Examination Survey 1999–2002

[摘要] We recently reported a relationship between serum concentrations of persistent organic pollutants (POPs) and diabetes mellitus in the general population(1). Furthermore, serum γ-glutamyltransferase (GGT) activity, even within its usual reference interval, strongly predicted type 2 diabetes in prospective studies through unclear mechanisms(2). Because exposure to high concentrations of POPs in occupational or accidental settings increased serum GGT(3), serum GGT may predict type 2 diabetes related to exposure to POPs. Thus, in the general population, low concentrations of POPs would be related to normal concentrations of serum GGT, and adjustment for POPs would attenuate the relationship of GGT and diabetes.This hypothesis was tested in the National Health and Nutrition Examination Survey (NHANES) 1999–2002 public-use dataset in 2016 persons ≥20 years of age. Serum concentrations of POPs and GGT activity were measured by highresolution gas chromatography/high-resolution mass spectrometry and by a Hitachi 737 analyzer, respectively. We selected the 6 POPs for which at least 80% of study participants had concentrations greater than …

[学科分类] 过敏症与临床免疫学