A Cause of Apparently Abnormal Urinary 17-Hydroxy Corticosteroids Responses to Metyrapone in Normal Subjects

[摘要] The metyrapone test is used to evaluate adrenal and pituitary disorders. The response to metyrapone administration can be erroneously interpreted as negative if a method that includes benzene— water partition is used to measure urinary 17-hydroxy corticosteroids. The reason for this is that benzene—water partition excludes most of the tetrahydrodeoxycortisol from the final extract, although this is the urinary steroid metabolite that increases after metyrapone administration.

[学科分类] 过敏症与临床免疫学