Survival Related to Plasma C-Reactive-Protein in Nonagenarians Is Modified by Apolipoprotein E Genotype

[摘要] In the present study, we combined 2 thoroughly studied markers of inflammation and lipid metabolism—sensitive C-reactive protein (hsCRP) and apolipoprotein E genotype (apoE)—to predict mortality in the elderly (1)(2). Plasma hsCRP concentration (1) and apoE genotype(2) are both important predictors of coronary artery disease (CAD) and stroke (1)(2). The risk of myocardial infarction in people with hsCRP concentrations in the highest third of the population range is twice that of those with hsCRP in the lowest third (1). ApoE genotype is a key regulator of lipoprotein metabolisms (2)(3), and the ε4-allele has been associated with increased plasma LDL cholesterol concentration and CAD (2)(3). These 2 factors are biologically linked; low hsCRP concentrations have been measured in apoE ε4-allele carriers, indicating that variation in plasma hsCRP concentration is partially determined by the common apoE (ε2, ε3 and ε4) gene polymorphism (3)(4).ApoE ε4 allele …

[学科分类] 过敏症与临床免疫学