Effect of Serum Gamma-Glutamyltransferase and Obesity on the Risk of Dyslipidemia and Poor Glycemic Control in Type 2 Diabetic Patients: Cross-Sectional Findings from the Verona Diabetes Study

[摘要] We read with interest the article by Lim et al. (1) regarding a strong interaction between serum gamma-glutamyltransferase (GGT) activity and body mass index (BMI) and their effect on the risk of prevalent diabetes. The authors found that BMI is associated with prevalent diabetes only among individuals with high-normal GGT, suggesting that GGT determination can be useful in clinical settings for identifying individuals at high risk for diabetes.Given the scientific and clinical importance of an interaction between obesity and GGT in predicting diabetes, we investigated possible interactions between BMI and GGT in predicting poor glycemic control and common comorbidities of diabetes. Therefore, we assessed whether the association of BMI with hypertension, dyslipidemia, and poor glycemic control differed according to serum GGT activities in a type 2 diabetic population.Study participants were enrolled in the Verona Diabetes Study, a prospective observational study designed primarily to evaluate associations between type 2 diabetes and incidence of cardiovascular complications (2). In this analysis, we included …

[学科分类] 过敏症与临床免疫学