Use of Intraoperative Samples to Optimize Efficacy of Central Laboratory Parathyroid Hormone Analyses

[摘要] Intact (1-84) parathyroid hormone (PTH) has a short half-life and can be monitored during surgery to confirm the removal of all hyperfunctioning parathyroid tissue, but exact criteria for timing of sample collection and number of samples that best indicate a surgical cure are still to be perfected (1). We report the degree of accuracy of our protocol of performing only 2 intraoperative PTH tests in patients undergoing parathyroidectomy.Sixty patients (43 women, 17 men; mean age 59.8 years, range 22–79 years), without renal failure, who underwent a minimally invasive surgical operation for sporadic primary hyperparathyroidism, participated in the study. Blood was collected from a peripheral vein before skin incision (basal or t-0) and 10 min after parathyroidectomy (t-10). The removal of the hyperfunctioning gland(s) was considered effective when the PTH decrease was ≥50% from the t-0 value (2). We measured the t-0 concentration before skin incision because physical manipulation …

[学科分类] 过敏症与临床免疫学