Simplified Primary Screening Procedure for Detection of Hyperlipidemias in Healthy Individuals

[摘要] A simplified primary screening procedure is described for determining serum β- plus pre-β-lipoproteins, which is more rapid and less expensive than cholesterol or triglyceride determinations. This method is based on the ability of β- and pre-β-lipoproteins to form insoluble complexes with heparin in presence of Ca2+. Comparison with analytical ultracentrifugation indicated the accuracy of concentrations determined by the present method. This method was used to screen a group of healthy adults and children and diabetic patients. The results show that measuring serum β- plus pre-β-lipoprotein concentrations may be more useful for screening and detecting subtle abnormalities than is determination of either cholesterol or triglyceride.

[学科分类] 过敏症与临床免疫学