Tyrosinemia Induced by a Pyridoxine Antagonist, Desoxypyridoxine

[摘要] Tyrosinemia was produced in Wistar rats by feeding a diet deficient in vitamin B6, and containing 1 mg of 4-desoxypyridoxine (DOP) per 100 g of diet. Concentrations of serum tyrosine were greatest in lactating rats, with smaller increases in nonpregnant, nonlactating females and adult males. Paper chromatography of urine indicated that DOP feeding also probably inhibits formation of most normal urinary metabolites of tyrosine. Livers of several rats showed no evidence of cirrhosis after 18 days on the diet containing DOP, indicating that this experimentally produced tyrosinemia is not a true model of tyrosinosis.

[学科分类] 过敏症与临床免疫学