Implication of Creatinine and Gut Flora in the Uremic Syndrome: Induction of "Creatininase" in Colon Contents of the Rat by Dietary Creatinine

[摘要] "Creatininase" activity was induced in the colon flora of rats by feeding creatinine. Sarcosine and methylamine were tentatively identified as the major products of the enzymic action. A third (unidentified) compound was observed. These compounds and methylguanidine were labeled in the urine of rats given 14CH3-creatinine orally. The results suggest that creatinine should not be considered biologically inert in animals, especially in those with decreased renal function.

[学科分类] 过敏症与临床免疫学