Direct-Contact (Membraneless) Hemoperfusion through Oils

[摘要] Oil-hemoperfusion is a highly promising procedure, as indicated by in vitro feasibility studies with human blood and in vivo experiments with rhesus monkeys. Direct liquid—liquid extraction is used to remove toxic or unwanted substances from whole blood. By choosing the proper oil or modification of an oleaginous liquid, cholesterol, total bilirubin, and lipid-soluble drugs such as glutethimide can be selectively removed or adjusted to the desired concentration with a single liquid—liquid extraction. Damage or loss of cellular components such as erythrocytes, leukocytes, and platelets is immeasurably small or nonexistent. Undesirable extraction of other vital biological substances and (or) back extraction of substances from the oil into the blood is so small that side effects or aftereffects of in vivo oil-hemoperfusion studies were considerably less than anticipated.

[学科分类] 过敏症与临床免疫学