Additive-Aggravated Assays: An Authoritative Answer

[摘要] Immunoassay interferences are diverse in scope (1)(2)(3)(4)(5)(6)(7)(8) and are the subject of several recent large-scale studies (9)(10), opinions, and editorials (6)(11). Most interferences originate from components of the sample (e.g., human antianimal antibodies, lipid, bilirubin, drug metabolites) that interact with assay reagents or the detection system.The latest interference to rear its ugly head has been an interference originating from an additive in a blood collection tube (12)(13)(14). In this issue of Clinical Chemistry , Remaley et al. (13) have extended their original work (12) on this problem and have now identified a common tube surfactant as the probable …

[学科分类] 过敏症与临床免疫学