Commentary

[摘要] Zur and colleagues have reported on the identification of a novel β-globin mutation that produced a hemoglobin with decreased oxygen affinity in a 4-year-old boy with poor physical resistance to stress. Mutations in both the α- and β-globin genes that produce low-affinity variants have been reported, although low-affinity hemoglobin variants are rare compared with high-affinity variants (1, 2). Mild anemia with decreased oxygen saturation and decreased erythropoietin is usually noted, and cyanosis may also be present in some …

[学科分类] 过敏症与临床免疫学