Commentary

[摘要] The authors faced a very challenging patient, whose imaging and laboratory results suggested the presence of an ACTH-secreting tumor. Several laboratory findings could have been erroneously attributed to 2 phenomena, “big ACTH” and complexes of ACTH with immunoglobulin, that occur in patients with ACTH-secreting tumors and affect measurement of ACTH.In the normal pituitary, ACTH is made by proteolytic processing of the precursor molecule proopiomelanocortin. When processing is faulty, as occurs in some cases of ectopic production of ACTH by tumors, a …

[学科分类] 过敏症与临床免疫学