Commentary

[摘要] Khani and Roshal describe a patient whose diagnosis of combined deficiencies of factors V and VIII was clarified nearly 20 years after the patient was diagnosed with “hemophilia.” A key clue to the correct diagnosis is that both the prothrombin time (PT) and the activated partial thromboplastin time (aPTT) are prolonged. Although we often speak of these tests as assays for 2 separate biochemical cascades, these cascades do not reflect clot formation in vivo. Rather, with vessel damage, tissue factor is exposed and complexes with factor VIIa …

[学科分类] 过敏症与临床免疫学