Changes in the Serum Protein Levels During Wound Tissue Regeneration

[摘要] The effect of wounding and formation of regenerating wound tissue on the level of the serum proteins was studied in rats on a protein-free diet. It was found that the level of the globulin component having the third greatest electrophoretic mobility, probably part of the α2-globulin fraction, rose about 60% within 3 days after wounding and did not begin to return to normal until about 10 days later. Concomitantly, the level of the globulin with least mobility, presumably the -globulin component, decreased about 35% and also began to return to normal within 2 weeks after wounding. Varying the rate of healing, by the addition of protein or methionine to the diet, had no effect on the changes in the serum globulin levels. The newly formed α2-globulins were shown to be distinct from fetuin.

[学科分类] 过敏症与临床免疫学