Interlaboratory Comparison of Thyroglobulin Measurements for Patients with Recurrent or Metastatic Differentiated Thyroid Cancer

[摘要] Serum thyroglobulin (Tg) is a tumor marker for persistent and recurrent thyroid cancer (1). However, there are technical limitations of Tg measurements by both RIA and two-site immunometric assays, and Tg results vary among laboratories (1)(2). Some of the discrepancy is likely linked to Tg autoantibody (TgAb) interference as TgAb is detectable by RIA in 18–40% of patients with differentiated thyroid cancer (3)(4). Failure to use the same Tg standard, preferably International Standard CRM-457, is potentially another source of interlaboratory differences in results (5)(6).In January 1999, we implemented a protocol by which we administer rhTSH (Thyrogen; Genzyme Transgenics Corporation) to patients with thyroid cancer. Serum Tg is measured before and 72 h after 2 days of rhTSH administration. University of Southern California (USC) Endocrine Services Section served as the central laboratory for the original Thyrogen protocol study sites from which the recommendations concerning the interpretation of rhTSH-stimulated Tg concentrations were derived (7). From January 1999 through July 2001, we split serum samples from these patients and sent them for …

[学科分类] 过敏症与临床免疫学