Platelet kinetics and thrombogenesis

[摘要] This synopsis focuses primarily on platelet kinetics, the role of platelets in thrombosis andthe effect of inhibition of platelet function on thrombosis. It highlights our contribution tothese fields of study. Key references are given as footnotes. Our own publications arecited in parentheses. For purposes of clarity, the publications are grouped under threeheadings. Those in the first group deal with the methods that we developed to isolate arepresentative and viable population of platelets from blood, to effectively label them withIn-Ill and to accurately quantify their in vivo distribution. They also address normalplatelet kinetics and explain what information can be deducted from kinetic studies.Those in the second group describe how we used In-Ill-platelets as an investigative toolto study various aspects of platelet function utilising several approaches in patients andexperimental animals. Those in the third group describe our contribution to assess theeffective use of agents developed to inhibit specific components of the thrombotic process.

[发布机构] University of the Free State