Penetration enhancement across a model membrane by liposomally entrapped drugs using N,N′‐diacylcystine as a bilayer lipid

[摘要]

A liposomal system for percutaneous absorption and transdermal drug delivery was developed and evaluated using a model apparatus connecting two chambers by a membrane. When N,N′-long chain diacyl L-cystine was incorporated into the liposomal bilayer as well lecithin and cholesterol, liposomally entrapped calccin as the model drug transferred well across the keratin membrane functioning as the skin model.

[学科分类] 生物化学/生物物理

[关键词] Liposomally entrapped drug;Penetration enhancement;N;N′-Diacyl L-cystine;Keratin membrane;PBS;phosphate-buffered saline;PABA;p-aminobenzoic acid;C8-SS;N;N′-dioctanoyl L-cystine;C12-SS;N;N′-dilauroyl L-cystine;DCP;dicetyl phosphate