Influence of prostaglandins on the lipid transfer between human high density and low density lipoproteins

[摘要]

Prostaglandin (PG) E₁ was demonstrated to stimulate the transfer of phosphatidylcholine and cholesterol esters from human high density lipoproteins (HDL₃) to low density lipoproteins (LDL). The enhancement effect of PGE₁, on the interlipoprotein lipid transfer was seen at low PG concentrations under conditions of spontaneous exchange as well as in the presence of lipoprotein-depleted plasma, or partly purified plasma lipid exchange protein. PGE₂ and PGF_2α showed no significant influence on the interlipoprotein lipid transfer. Evidence is presented suggesting that the PGE₁-induced stimulation of interlipoprotein lipid exchange results in enhancement of LCAT-catalyzed cholesterol esterification in plasma. It is proposed that the effect of PGE₁ is due to the previously described PGE₁-induced reorganization of the HDL surface [(1984) FEBS Lett. 173, 291-293] and that PG-lipoprotein interaction may be a factor regulating cholesterol homeostasis.

[学科分类] 生物化学/生物物理

[关键词] Prostaglandin;Lipid transfer;Cholesterol esterification;LDL;HDL;(Human);PG;prostaglandins;DPPC;dipalmitoylphosphatidylcholine;HDL;high density lipoproteins;LDL;low density lipoproteins;LEP;lipid exchange protein;LDP;lipoprotein-depleted plasma;LCAT;lecithin:cholesterol acyltransferase (EC 2.3.1.43)