Tetrazole analogs of amino acids as constituents of modifiers of carboxypeptidase A catalysis

[摘要]

The action of substrate analogs containing the tetrazolyl group instead of the C-terminal carboxy group on the peptidase activity of carboxypeptidase A is studied. The analogs compete with the substrate for the secondary binding site thus showing activation phenomena.

[学科分类] 生物化学/生物物理

[关键词] Carboxypeptidase A;Substrate analog;Competitive activator;Secondary binding site;Amino acid analog;Z;benzyloxycarbonyl;H-Gly-T;5-aminomethyl-I(2)H-tetrazole;H-Phe-T;L-5-α-aminophen-ylethyl-I(2)H-tetrazole;T;5-substituted tetrazolyl group;ONp;p-nitrophenyl ester