Biosynthesis and activity of DNA polymerase throughout the mitotic cycle of Physarum polycephalum

[摘要]

Measurements of DNA polymerase protein levels and polymerase activity through the naturally synchronous mitotic cycle of Physarum polycephalum show that active DNA polymerase-α is synthesized throughout the G₂ phase, in step with the profile of general protein biosynthesis. Three main components of P. polycephalum DNA polymerase of 200, 112 and 70 kDa were found to be immunologically related.

[学科分类] 生物化学/生物物理

[关键词] DNA polymerase-α;Cell cycle;(Physarum polycephalum)