Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage‐dependent Na+ channel

[摘要]

Binding studies indicate that ciguatoxin and brevetoxin allosterically enhance in a very similar way the binding of [³H]batrachotoxinin A 20-α-benzoate to the neuronal Na⁺ channel protein. Moreovr ciguatoxin competitively inhibits the binding of [³H]brevetoxin-3 to rat brain membranes. The affinity of ciguatoxin for the Na⁺ channel is at least 20–50-times higher than that of brevetoxin. These results indicate that ciguatoxin and brevetoxins act at the same binding site on the sodium channel.

[学科分类] 生物化学/生物物理

[关键词] Ciguatoxin;Na channel;Ciguatera;Brevetoxin;Receptor;Pyrethroid;AS2;Anemonia sulcata toxin 2;[3H]BTX-B;[3H]batrachotoxinin A 20-α-benzoate;CgTx;ciguatoxin;PbTx;brevetoxin (Ptychodiscus brevis toxin);TTX;tetrodotoxin