Differential penetration of fatty acyl‐coenzyme A and fatty acylcarnitines into phospholipid monolayers

[摘要]

The ability of fatty acyl-CoA's and fatty acylcarnitines to penetrate phospholipid monolayers was comparatively studied, in view of the important role of both kinds of derivatives in fatty acid transport across mitochondrial membranes. The interaction occurs predominantly through hydrophobic forces. Acylcarnitines penetrate phospholipid monolayers more strongly than acyl-CoAs; in addition the former show a positive cooperativity when they bind to the interface. These properties would facilitate membrane transfer of fatty acylcarnitines over that of their CoA homologues.

[学科分类] 生物化学/生物物理

[关键词] Fatty acyl-coenzyme A;Fatty acylcarnitine;Phospholipid monolayer;Model membrane;Δπ;increase in surface pressure;CoA;coenzyme A;DMPA;dimyristoyl phosphatidic acid;DMPC;dimyristoyl phosphatidylcholine;DPPC;dipalmitoyl phosphatidylcholine;DPPE;dipalmitoyl phosphatidylethanolamine;EYPC;egg-yolk phosphatidylcholine;Pa-CoA;palmitoyl-coenzyme A;PaCar;palmitoylcarnitine;PC;phosphatidylcholine