Differential effect of phenobarbital and β‐naphthoflavone on the mRNAs coding for cytochrome P450 and NADPH cytochrome P450 reductase

[摘要]

The induction in rat liver of a specific variant(s) of cytochrome P450 (PB-P450) by phenobarbital and its repression by β-naphthoflavone occur through corresponding changes in the levels of mRNA coding for the protein(s). The level of translatable mRNA coding for NADPH-cytochrome P450 reductase in rat liver increases on treatment with phenobarbital but not β-naphthoflavone.

[学科分类] 生物化学/生物物理

[关键词] Cytochrome P450;NADPH cyt. P450 reductase;mRNA;Immunoprecipitation;Phenobarbital;β-Naphthoflavone;PB;phenobarbital;β-NF;β-naphthoflavone;PB P450;major inducible cytochrome P450 variant of M r 52 000